Effect of sodium saccharin on rat pancreatic enzyme secretion

Intragastric administration of casein, oleic acid, or polyvinylpyrrolidone resulted in a marked increase in the pancreatic secretion of enzymes, and the administration of 0.03% sodium saccharin, at the concentration permitted in soft drinks, inhibited this increase with these substances. The stimulation of secretion of pancreatic juice-bile mixture by these substances was also inhibited by administration of sodium saccharin. Intravenous injection of CCK-PZ (cholecystokinin-pancreozymin) during inhibition by sodium saccharin, caused a rapid increase in amylase output, suggesting that sodium saccharin acts on the site(s) of CCK-PZ release to prevent its secretion even in the presence of a stimulant, but does not reduce the sensitivity of the pancreas to CCK-PZ. Sodium saccharin seemed to have an effect on secretin release similar to that on CCK-PZ release, judging from the results for the volume of juice-bile mixture.