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Poly(ADP-ribose) polymerase is a zinc metalloenzyme

P Zahradka, K Ebisuzaki

    European Journal of Biochemistry
    |August 1, 1984
    PubMed
    Summary

    Poly(ADP-ribose) polymerase, an enzyme crucial for DNA repair, requires zinc for its activity. Inhibitors that chelate metals, like 1,10-phenanthroline, block enzyme function by removing zinc, indicating its metalloprotein nature.

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