Related Experiment Videos
[Intraocular penetration of ceftriaxone in man. Comparison with other beta-lactamins]
Abstract:
The intraocular penetration of a new antibiotic, ceftriaxon, was studied in 30 patients. Serum samples in 29 patients showed an average level of 42 micrograms/ml. Penetration into the aqueous humour flow studied in 28 patients under general anesthesia at one, two, three, four and six hours after the injection. An average level of 0,53 micrograms/ml was found which is 1,25% of average serum level. In 23 patients the dry level in tears averaged 5,75 micrograms/ml (13% of the serum level). In one case of retinal detachment the level in the subretinal fluid was 1,56 micrograms/ml. The kinetics drug secretion in tears was studied in 3 patients without anesthesia every 2 hours until the 16 th to 22 nd hours. Lower levels than those obtained under general anesthesia were obtained. This study shows that ceftriaxon has an intraocular penetration at levels above the minimal inhibitory concentrations for most commun intraocular infection.
Insights
This study demonstrates that the antibiotic ceftriaxone effectively penetrates the eye, reaching concentrations in ocular fluids like aqueous humor and tears that are significant for treating intraocular infections.
Area of Science:
- Ophthalmology
- Pharmacology
- Infectious Diseases
Background:
- Intraocular infections require antibiotics with sufficient ocular penetration.
- Ceftriaxone is a third-generation cephalosporin with broad-spectrum activity.
Purpose of the Study:
- To evaluate the intraocular penetration of ceftriaxone in patients.
- To determine ceftriaxone concentrations in aqueous humor and tears.
Main Methods:
- Serum, aqueous humor, tear, and subretinal fluid levels of ceftriaxone were measured in patients.
- Pharmacokinetic analysis of drug secretion in tears was performed under general anesthesia and without.
Main Results:
- Average aqueous humor concentration was 0.53 µg/ml (1.25% of serum levels).
- Average tear concentration was 5.75 µg/ml (13% of serum levels).
- Subretinal fluid level was 1.56 µg/ml in one case; tear levels were lower without anesthesia.
Conclusions:
- Ceftriaxone achieves intraocular concentrations above the minimum inhibitory concentrations for common ocular pathogens.
- The antibiotic shows promising potential for treating intraocular infections.