[Physiologically active peptides and the regulation of arterial pressure in normal and pathological states]

Relation between kallikrein-kinin and renin-angiotensin polypeptide blood systems, main regulators of arterial pressure, is considered. Activities of kallikrein, renin and angiotensin-converting enzyme were studied in healthy persons and in patients with various forms of renin-dependent arterial hypertension under conditions of immobility and after physical loading. In dynamics of hereditary-determined hypertension of rats there were studied the effects of bradykinin and angiotensin II on alterations in reactivity of the vascular bed as well as on alterations in lung metabolic functions. A scheme of functionally important relations between the factors of neurohumoral regulation of arterial blood pressure is developed involving direct and reverse interactions between the blood pressure and depressive components of the polypeptide systems.