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[Ketoconazole and onychomycosis].

D Parent, G Achten, J André

    Annales De Dermatologie Et De Venereologie
    |January 1, 1984
    PubMed
    Summary
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    Ketoconazole effectively treats onychomycosis, achieving high recovery rates for fungal nail infections caused by dermatophytes and yeasts. This antifungal medication is well-tolerated, though regular monitoring is advised.

    Area of Science:

    • Medical Mycology
    • Dermatology
    • Pharmacology

    Context:

    • Onychomycosis is a common fungal nail infection.
    • Treatment options for onychomycosis can be limited and require prolonged therapy.
    • Ketoconazole is a broad-spectrum antifungal agent.

    Purpose:

    • To evaluate the efficacy and safety of daily oral ketoconazole in treating onychomycosis.
    • To determine recovery rates and treatment durations for different causative agents of onychomycosis.

    Summary:

    • 48 patients with onychomycosis (dermatophytes, yeasts, Scopulariopsis brevicaulis) received 200 mg ketoconazole daily.
    • Recovery rates were 65% for dermatophyte infections and 80% for Candida infections.
    • Average treatment duration varied by nail site and causative agent; side effects were minimal and primarily gastrointestinal.

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    Impact:

    • Ketoconazole demonstrates effectiveness against various fungal pathogens causing onychomycosis.
    • The drug is generally well-tolerated, with minimal side effects reported in this study.
    • Regular monitoring is recommended due to potential adverse reactions, and patients with comorbidities should exercise caution.