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Modelling the ATP-binding site of oncogene products, the epidermal growth factor receptor and related proteins
FEBS Letters
|October 1, 1984
Abstract:
A three-dimensional model for the ATP-binding site of the oncogene product v-src is proposed by the use of interactive computer graphics. A similar model would apply to sequence related proteins such as other oncogene products, the epidermal growth factor receptor, cAMP-dependent protein kinase and the cell division control protein CDC28. The model was proposed on the basis of the conservation of certain key residues between the oncogene product family of proteins and several nucleotide binding proteins of known structures.
Insights
A 3D model of the v-src oncogene
Area of Science:
- Biochemistry
- Structural Biology
- Oncology
Background:
- The v-src oncogene product is implicated in cancer.
- Understanding the ATP-binding site is crucial for drug development.
Purpose of the Study:
- To propose a three-dimensional model of the ATP-binding site of the v-src oncogene product.
- To identify conserved residues for potential drug targeting.
Main Methods:
- Interactive computer graphics were utilized.
- Comparative analysis of conserved residues between v-src and known nucleotide-binding proteins.
Main Results:
- A detailed 3D model of the v-src ATP-binding site was generated.
- Key conserved residues were identified, suggesting potential for broad applicability.
Conclusions:
- The proposed model provides insights into v-src function.
- The model is applicable to related proteins like EGFR and protein kinases, aiding in the design of targeted therapies.