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Small cell carcinoma of urinary bladder. Ultrastructural study.
Urology
|October 1, 1984
Summary
This study presents two cases of small cell carcinoma of the urinary bladder. These tumors microscopically resemble lung oat cell carcinoma but lack neuroendocrine features, suggesting a transitional epithelium origin.
Area of Science:
- Urology
- Oncology
- Pathology
Background:
- Small cell carcinoma is a rare malignancy of the urinary bladder.
- It shares histological similarities with small cell carcinoma of the lung.
Observation:
- Two cases of urinary bladder small cell carcinoma presented with polypoid gross appearance.
- Microscopic examination revealed features resembling lung oat cell carcinoma.
Findings:
- Ultrastructural analysis did not identify neuroendocrine cells or neurosecretory granules.
- Histogenesis appears to originate from undifferentiated cells within the transitional epithelium.
Implications:
- This finding challenges the neuroendocrine origin for bladder small cell carcinoma.
- Further research into the histogenesis of this rare bladder cancer is warranted.