Tetanic stimulation affects the metabolism of phosphoinositides in hippocampal slices

Tetanic but not low frequency stimulation of the perforant path in rat hippocampal slices results in changes in the metabolism of phosphoinositides and phosphatidic acid. The phosphorylation of other, non-inositol lipids was not affected by the high frequency stimulation. The observed changes in phosphoinositide metabolism are complex and biphasic, lasting at least 4 h after the termination of the tetanus. The present data support the notion that membrane phosphoinositides play a role in synaptic function.