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Related Experiment Videos

Advances in antiviral therapy: acyclovir.

E G Chadwick, S T Shulman

    Pediatric Dermatology
    |July 1, 1984
    PubMed
    Summary

    Acyclovir, a new antiviral drug, effectively treats herpes simplex virus (HSV) and varicella zoster virus (VZV) infections. Its therapeutic applications are expanding as research continues on this promising medication.

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    Area of Science:

    • Virology
    • Pharmacology
    • Antiviral Therapeutics

    Background:

    • Acyclovir is a novel acyclic nucleoside analog.
    • It demonstrates in vitro and in vivo activity against herpes simplex virus (HSV) and varicella zoster virus (VZV).

    Purpose of the Study:

    • To review the current status and therapeutic role of acyclovir.
    • To discuss its efficacy against HSV and VZV infections.

    Main Methods:

    • Review of existing clinical trial data and in vitro/in vivo studies.
    • Analysis of the pharmacological profile of acyclovir.

    Main Results:

    • Acyclovir is active against HSV and VZV.
    • Topical and intravenous formulations are available in the US.
    • Oral acyclovir is under clinical evaluation.

    Conclusions:

    • Acyclovir represents a significant advancement in antiviral therapy for herpesvirus infections.
    • The precise clinical role of acyclovir is still being defined but shows great promise.

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