The use of aromatic carbonyl derivatives in pharmaceutical analysis. Part 1

The pharmaceutical analytical utility of one the aromatic carbonyl derivatives, namely 2-hydroxy-1-naphthaldehyde isonicotinyl hydrazone, was investigated. It was prepared and utilized for the colorimetric determination of Fe2+ in the presence of other metals, and for the determination of Fe3+. It was also utilized in the determination of Fe2+ in the presence of Fe3+, vitamins hormones, and tablet ingredients likely to be present in combination with Fe2+ in geriatric mixtures. A proposed colorimetric assay for ferrous sulphate tablets is presented and compared with the Brit. Ph 1968 method. The reaction of the chelating agent with other metal ions is described, and its chelate-combining ratio with iron Fe2+ and Fe3+ was determined.