[Dynamics of changes in the neuronal function of the central nervous system under prolonged stimulations]

Mechanisms involved in long-term stimulation of the c. n. s. neurons of different degrees of complexity (cats, molluscs,) were studied. The hypoxic effect and prolonged transmembrane depolarization of a single neuron were used as long-term stimulation. The pattern of electrophysiological properties of neurons was investigated with microelectrode technique, fixation of potential and intracellular dialysis. The experiments showed that the hypoxic effect converted the neuron from the state of excitation into the state of depolarization inhibition. This reaction of the neuron was shown to be connected with the primary activation followed by a slow inactivation of the channels of input current.