Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Age-associated decrease of dopamine-sensitive adenylate cyclase in rabbit renal artery.

F Amenta, C Cavallotti, W L Collier

    Neuroscience Letters
    |October 26, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Crossed-beam and theoretical studies of multichannel nonadiabatic reactions: branching fractions and role of intersystem crossing for O(<sup>3</sup>P) + 1,3-butadiene.

    Faraday discussions·2022
    Same author

    EStokTP: Electronic Structure to Temperature- and Pressure-Dependent Rate Constants-A Code for Automatically Predicting the Thermal Kinetics of Reactions.

    Journal of chemical theory and computation·2018
    Same author

    H-Abstraction reactions by OH, HO<sub>2</sub>, O, O<sub>2</sub> and benzyl radical addition to O<sub>2</sub> and their implications for kinetic modelling of toluene oxidation.

    Physical chemistry chemical physics : PCCP·2018
    Same author

    Efficacy of an emollient dermoprotective cream in the treatment of elderly skin affected by xerosis.

    Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia·2015
    Same author

    Immunologic biomarkers for clinical and therapeutic management of psoriasis.

    Mediators of inflammation·2014
    Same author

    Cholinergic innervation of human mesenteric lymphatic vessels.

    Folia morphologica·2014
    Same journal

    Dynorphinergic neuroadaptations in the islands of Calleja: implications for alcohol use disorder.

    Neuroscience letters·2026
    Same journal

    Differential vulnerability of cochlear nuclei to Lmx1 deficiency: abnormal patterning and implications for auditory circuitry.

    Neuroscience letters·2026
    Same journal

    Role of nNOS/sGC pathway in the insular cortex in control of cardiovascular, autonomic and corticosterone responses to restraint stress in rats.

    Neuroscience letters·2026
    Same journal

    Jak1 inhibition reduces acute allodynia induced by specific upstream cytokines in rats: implications for the onset of Jak1 pain modulation.

    Neuroscience letters·2026
    Same journal

    Glucocorticoids-induced depressive-like behaviors in mice: oral ingestion of corticosterone or hydrocortisone - A comparative study.

    Neuroscience letters·2026
    Same journal

    Data-driven clustering of prefrontal activation identifies functional phenotypes under prioritized dual-task walking conditions in Parkinson's disease.

    Neuroscience letters·2026
    See all related articles

    Dopamine

    Area of Science:

    • Gerontology
    • Pharmacology
    • Cardiovascular Research

    Background:

    • Aging impacts physiological functions, including the cardiovascular system.
    • Dopamine plays a role in regulating vascular tone and cellular signaling.
    • The dopaminergic system's function in peripheral arteries across the lifespan is not fully understood.

    Purpose of the Study:

    • To investigate the effect of dopamine on cyclic adenosine monophosphate (cAMP) generation in rabbit renal arteries across different age groups.
    • To determine if aging affects basal adenylate cyclase activity or protein content in renal arteries.
    • To compare the dopamine-induced cAMP response in young, mature, and old rabbits.

    Main Methods:

    • Renal arteries were obtained from rabbits of three age groups: young (6 months), mature (18 months), and old (70 months).

    Related Experiment Videos

  • Basal adenylate cyclase activity and protein content were measured in renal artery homogenates.
  • The effect of dopamine on cAMP generation was assessed in these arterial tissues.

    • Main Results:

    • No significant differences in basal adenylate cyclase activity or protein content were observed among the age groups.
    • Dopamine significantly stimulated cAMP production in all age groups.
    • The stimulatory effect of dopamine on cAMP generation was reduced by approximately 40% in old rabbits compared to young and mature rabbits.

    Conclusions:

    • Aging does not alter basal adenylate cyclase activity or protein levels in rabbit renal arteries.
    • The peripheral dopaminergic system's responsiveness to dopamine is impaired in aged rabbits.
    • This age-related impairment in the peripheral dopaminergic system may mirror changes observed in the central nervous system.