The effect of thymoxamine on guinea-pig ileum contractions

The effects of thymoxamine on the contractions induced in guinea-pig isolated ileum were examined. The drug was tested in a large range of concentrations (10(-8)-10(-4) M). The twitch response induced by acetylcholine was potentiated by low concentrations and inhibited by high concentrations of the alpha 1-blocking drug thymoxamine. The contractions in response to carbachol were always inhibited. Thymoxamine also affected the responses of the ileum to other stimulants: angiotensin, pentagastrin, cholecystokinin. The drug (8 X 10(-5), 5 X 10(-4) M) inhibited the calcium contraction of high K+ depolarized preparations.