Single anion channels of frog rod plasma membrane

Anion channels have been found in the plasma membrane of the outer and inner segment of the isolated retinal rod by means of the patch voltage-clamp technique. The permeability of the channels for different anions follows a sequence: Cl- greater than F- greater than NO3- greater than propionate; the channel conductance in the fully open state is 200 +/- 30 pS measured in 108 mM NaCl. The non-linear character of the current-voltage relationship at membrane potentials from -40 to -20 mV suggests that these anion channels may be involved in receptor potential generation through an electrogenic mechanism.