Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Dermorphin interaction with peripheral opioid receptors.

G Giagnoni, D Parolaro, L Casiraghi

    Neuropeptides
    |December 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Impact of blood donation on serum cobalamin and folic acid concentrations in dogs.

    Australian veterinary journal·2026
    Same author

    Review: Improving residual feed intake modelling in the context of nutritional- and genetic studies for dairy cattle.

    Animal : an international journal of animal bioscience·2024
    Same author

    Feed intake in housed dairy cows: validation of a three-dimensional camera-based feed intake measurement system.

    Animal : an international journal of animal bioscience·2024
    Same author

    Fractional excretion of electrolytes and neutrophil gelatinase-associated lipocalin as early biomarkers of acute kidney injury in dogs with acute pancreatitis.

    The Journal of small animal practice·2023
    Same author

    The erythrocyte sedimentation rate (ESR) in canine inflammation.

    Veterinary journal (London, England : 1997)·2022
    Same author

    Effect of protein concentrate mixtures and dietary addition of exogenous phytase on major milk minerals and proteins, including casein phosphorylation.

    Journal of dairy science·2021
    Same journal

    The hemoglobin-derived peptide LVV-H7 attenuates select behavioral alterations in male spontaneously hypertensive rats.

    Neuropeptides·2026
    Same journal

    Neuropeptide Y in cancer metastasis and chemoresistance.

    Neuropeptides·2026
    Same journal

    Expression of the Galanin system in the human pancreas, pancreatitis, and pancreatic cancer: Association with nodal involvement and perineural invasion.

    Neuropeptides·2026
    Same journal

    PACAP promotes mitochondrial biogenesis in rat primary chondrocytes via the SIRT1/PGC-1α pathway.

    Neuropeptides·2026
    Same journal

    Galanin receptor 2: A multifunctional modulator in neurological diseases - Structure, mechanisms, and therapeutic prospects.

    Neuropeptides·2026
    Same journal

    Re-thinking neuropeptide therapeutics: What Neuropeptide Y and Galanin teach us about stress, resilience, and drug design.

    Neuropeptides·2026
    See all related articles

    Dermorphin primarily interacts with mu-opioid receptors and also binds to epsilon receptors. Its effects on delta receptors are uncertain, while kappa receptors remain unaffected by dermorphin.

    Area of Science:

    • Pharmacology
    • Neuroscience
    • Biochemistry

    Background:

    • Opioid receptors (mu, delta, kappa, epsilon) mediate diverse physiological effects.
    • Dermorphin is a peptide with potential opioid activity.
    • Understanding dermorphin's receptor interactions is crucial for its therapeutic applications.

    Purpose of the Study:

    • To investigate the interaction of dermorphin with peripheral opioid receptor subtypes in vitro.
    • To compare dermorphin's activity with selective opioid receptor agonists.
    • To determine the affinity of dermorphin for different opioid receptor subtypes.

    Main Methods:

    • In vitro assays using isolated peripheral tissues: guinea pig ileum (mu), mouse vas deferens (delta), rabbit vas deferens (kappa), and rat vas deferens (epsilon).

    Related Experiment Videos

  • Comparison of dermorphin's effects with selective agonists: morphine (mu), met-enkephalinamide (delta), ethylketocyclazocine (kappa), and camel beta-endorphin (epsilon).
  • Assessment of naloxone antagonism to calculate dissociation constants (Ke).

    • Main Results:

    • Dermorphin demonstrated significant interaction with mu-opioid receptors.
    • Dermorphin also exhibited binding to epsilon receptors.
    • The interaction with delta receptors was inconclusive, and kappa receptors were unaffected.

    Conclusions:

    • Dermorphin primarily acts as a mu-opioid receptor agonist.
    • Dermorphin possesses activity at epsilon receptors.
    • Further research is needed to clarify dermorphin's role at delta and epsilon receptors.