[Effect of vitamins A, D3 and E on intestinal motility in rabbits in chronic experiments and in vitro]

In chronic experiments and in vitro the motoricity of jejunum in rabbits was recorded under the influence of vitamins soluble in fats - A, D3 and E before and after blocking adrenergic or cholinergic receptors. In chronic experiments the vitamins were used at concentrations of 2 - 500 micrograms/ml, whereas in vitro 0.1 - 30 mg/ml. It was shown that vitamins A, D3, and E inhibited the motoric activity of the intestines, but the influence of the vitamins was stronger in chronic experiments than in vitro. The strongest action inhibiting the motoricity was shown by vitamin D3, then A and a very weak action by vitamin E. Neither adrenergic nor cholinergic receptors were shown to participate in the mechanism of action of the vitamins on intestine motoricity, which is likely to be connected with direct influence of the vitamins on smooth muscular coat of the intestines.