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Related Experiment Videos

Metastatic carcinoid to the choroid.

C A Minning1, F H Davidorf, T A Makley

  • 1Department of Ophthalmology, Ohio State University, Columbus.

Retina (Philadelphia, Pa.)
|January 1, 1982
PubMed
Summary

This case study details a patient with metastatic carcinoid tumor to the choroid treated with a radon ring implant. The therapy showed minimal tumor reduction and was ultimately ineffective, suggesting carcinoid tumors are radioresistant.

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Area of Science:

  • Ophthalmology
  • Oncology
  • Radiation Oncology

Background:

  • Metastatic carcinoid tumors can rarely affect the choroid.
  • Previous conservative treatments for choroidal carcinoid metastases include chemotherapy and radiation.
  • Surgical intervention like enucleation is a last resort for advanced cases.

Observation:

  • This report details the seventh case of metastatic carcinoid to the choroid.
  • The patient received a novel conservative therapy: implantation of a radon ring.
  • Initial clinical results were promising, but ultrasound showed minimal tumor size reduction.

Findings:

  • The radon ring implantation had minimal histologic effect on tumor cell viability.
  • A large retinal detachment led to significant visual deterioration.

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  • Enucleation was required due to persistent pain from neovascular glaucoma.

    • Implications:

    • Metastatic carcinoid tumors of the choroid appear relatively radioresistant.
    • External proton beam irradiation may be more effective for smaller choroidal lesions.
    • Further research into effective treatments for metastatic carcinoid to the choroid is warranted.