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Updated: Jun 3, 2026
08:35
Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion
Published on: May 26, 2022
Summary
Ranitidine hydrochloride, a new H2-receptor antagonist, shows dose-dependent plasma levels and gastric acid reduction. Oral bioavailability is approximately 50%, with a bimodal concentration curve in healthy subjects.
Area of Science:
- Pharmacology
- Gastroenterology
Background:
- Histamine H2-receptor antagonists are crucial for managing acid-related disorders.
- Understanding the pharmacokinetics and antisecretory effects of new agents is essential for clinical application.
Purpose of the Study:
- To investigate the pharmacokinetics of ranitidine hydrochloride in healthy subjects.
- To evaluate the gastric antisecretory effects of ranitidine hydrochloride.
Main Methods:
- Pharmacokinetic analysis involving oral and intravenous administration of ranitidine (20 mg, 40 mg, 80 mg) in six subjects.
- Gastric acid output measurement following intravenous ranitidine injections (20 mg, 40 mg, 80 mg) during pentagastrin stimulation in five subjects.
Main Results:
- Ranitidine plasma levels were dose-related, with a bimodal concentration-time curve observed after oral administration in most subjects.
- The estimated elimination half-life of ranitidine was 140 minutes.
- Oral bioavailability of ranitidine was approximately 50%.
- A statistically significant, dose-related reduction in gastric acid output was observed (P < 0.05).
Conclusions:
- Ranitidine hydrochloride exhibits predictable pharmacokinetics and effective gastric acid suppression.
- The drug's dose-dependent effects and bioavailability support its potential as a therapeutic agent.
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