Pharmacokinetics and pharmacodynamics of Org NC 45 in man

A combined pharmacokinetic--pharmacodynamic study of Org NC 45 was performed in six patients undergoing elective oro--facial surgery. The pharmacokinetics could be described using a two-compartment open model with a distribution half-life of approximately 4 min and an elimination half-life of approximately 31 min. The pharmacokinetic parameters confirm earlier clinical findings that Org NC 45 has a more rapid onset and a shorter duration of action than pancuronium, and a faster recovery rate. When comparing the pharmacokinetic and pharmacodynamic parameters the biophase could be distinguished from both the central and the peripheral compartments. The mean steady-state plasma concentration producing a 50% block of the twitch response was 0.137 microgram ml-1 (range 0.118--0.176 microgram ml-1).