[Hyper-immunoglobulin-prophylaxis and follow-up in vertical hepatitis B (author's transl)]

The vertical transmission of hepatitis-B virus from chronic HBsAg carrier mothers can cause acute even fatal hepatitis-B, or a chronic HBsAg carrier state in childhood. To prevent this vertical transmission, hepatitis-B- immunoglobulin (HB Ig) is applicated. Frequency and dosis-data are still confusing. Six children were passively immunized with HB Ig according to our schedule. Their serum was controlled for HBsAg and HBsAb with the RIA-method. None of these children became HBsAg positive.