[Pathogenesis and treatment of endotoxic shock]

In addition to foci of suppurative inflammation the cyclic income of bacteria and products of their decay into the general circulation from the zone of microcirculation may be responsible for the transit septic toxemia and endotoxic shock. Highly virulent bacteria which had lost the connection with the primary focus can find their temporary refuge and conditions for their reproduction in non-functioning rest capillaries with the closed precapillary sphincters. The author proposes a method of provocative-infusive antiseptic therapy aimed at opening the capillaries with the help of vasoleptic agents (novocain, gangliolytic drugs), the elimination of bacteria in the sites of their cultivation and in the vascular bed (stroke doses of antiseptic drugs of the purposeful action), accelerated release of toxins by forced diuresis (osmodiuretics) which was found to be effective in 8 of 9 patients with endotoxic shock.