Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Opioid peptides as intercellular messengers.

J C Schwartz, B P Roques

    Biomedicine / [Publiee Pour L'A.A.I.C.I.G.]
    |December 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Binding properties of a highly potent and selective iodinated aminopeptidase N inhibitor appropriate for radioautography.

    FEBS letters·2000
    Same author

    Effects of cationic charge on three-dimensional structures of intercalative complexes: structure of a bis-intercalated DNA complex solved by MAD phasing.

    Current medicinal chemistry·2000
    Same author

    The HIV-1 viral protein R induces apoptosis via a direct effect on the mitochondrial permeability transition pore.

    The Journal of experimental medicine·2000
    Same author

    Investigation of subsite preferences in aminopeptidase A (EC 3.4.11.7) led to the design of the first highly potent and selective inhibitors of this enzyme.

    Journal of medicinal chemistry·1999
    Same author

    Nucleic acid sequence discrimination by the HIV-1 nucleocapsid protein NCp7: a fluorescence study.

    Biochemistry·1999
    Same author

    In vitro evidence for the interaction of tRNA(3)(Lys) with U3 during the first strand transfer of HIV-1 reverse transcription.

    Nucleic acids research·1999
    Same journal

    Characterization of a major natural killer activity in rat lungs.

    Biomedicine / [publiee pour l'A.A.I.C.I.G.]·1981
    Same journal

    Decreased phagocytosis and antibody-dependent cellular cytotoxicity (ADCC) in type-1 diabetes.

    Biomedicine / [publiee pour l'A.A.I.C.I.G.]·1981
    Same journal

    [Alveolar macrophages in asthmatic patients: study of their phagocytic function].

    Biomedicine / [publiee pour l'A.A.I.C.I.G.]·1981
    Same journal

    Effect of salbutamol, a putative cerebral beta agonist on sleep stages and interictal epileptic discharges.

    Biomedicine / [publiee pour l'A.A.I.C.I.G.]·1981
    Same journal

    Ganglioside content and pattern in tumor tissue of human neuroblastomas.

    Biomedicine / [publiee pour l'A.A.I.C.I.G.]·1981
    Same journal

    Protective effect of levamisole on carbon tetrachloride-induced lipid peroxidation and hepatotoxicity.

    Biomedicine / [publiee pour l'A.A.I.C.I.G.]·1981
    See all related articles

    Opioid peptides, like enkephalins and beta-endorphin, are endogenous substances acting as messengers in the central nervous system and tissues via opiate receptors. They function as neurotransmitters or hormones, facilitating cellular communication.

    Area of Science:

    • Neuroscience
    • Endocrinology
    • Molecular Biology

    Background:

    • Opioid peptides are endogenous signaling molecules found in the central nervous system and peripheral tissues.
    • Their biological actions are primarily mediated through interactions with specific opiate receptors.
    • These peptides exist in different molecular weight classes, including short peptides and larger molecules.

    Purpose of the Study:

    • To elucidate the dual roles of opioid peptides as intercellular messengers.
    • To differentiate the functions of various classes of opioid peptides.
    • To understand the mechanisms of action of enkephalins and beta-endorphin.

    Main Methods:

    • Characterization of endogenous opioid peptides.
    • Analysis of their distribution in the central nervous system and tissues.

    Related Experiment Videos

  • Investigation of their receptor binding properties.
  • Functional assays to determine neurotransmitter and hormone activity.

    • Main Results:

    • Opioid peptides are classified into distinct groups based on molecular weight.
    • Enkephalins function as neurotransmitters within the central nervous system.
    • Beta-endorphin acts as a hormone, signaling through the bloodstream or other pathways.
    • Both peptide classes mediate their effects via opiate receptors.

    Conclusions:

    • Opioid peptides are crucial endogenous messengers with diverse roles.
    • Enkephalins and beta-endorphin represent key examples of neurotransmitter and hormone functions, respectively.
    • Understanding these roles is vital for comprehending neural and endocrine signaling pathways.