Comparison of sodium and stannous fluoride nephrotoxicity

Single i.p. injections of 0.5 mmol F-/kg and repeated i.p. injections of 0.25 mmol F-/kg as NaF or SnF2 to male rats showed that both compounds produced early lesions of kidney tubule demonstrated by an intense increase of urine gamma-glutamyl transferase (GGT). Disturbance of kidney function with an increase of diuresis and phosphaturia and a decrease of natriuria and kaliuria were more marked in SnF2-treated animals as was the decrease of urine GGT after a few days. These results indicate that tin nephrotoxicity adds to that of fluoride and antagonizes tubule regeneration.