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[Rotavirus in acute gastroenteritis (author's transl)]
Summary
Rotavirus infections are common in infants with acute gastroenteritis, particularly those under six months old. Enzyme-linked immunosorbent assay is recommended for accurate rotavirus detection in diagnosing gastroenteritis.
Area of Science:
- Virology
- Pediatric Infectious Diseases
- Diagnostic Immunology
Context:
- Acute gastroenteritis is a significant health concern, especially in infants.
- Enteropathogenic Escherichia coli (E. coli) is often suspected in pediatric gastroenteritis cases.
- Limited data exists on the co-occurrence of rotavirus and enteropathogenic E. coli in this demographic.
Purpose:
- To determine the prevalence of rotavirus in infants with acute gastroenteritis.
- To compare the diagnostic sensitivity of enzyme-linked immunosorbent assay (ELISA) and complement fixation (CF) for rotavirus detection.
- To investigate the co-infection rate of rotavirus and enteropathogenic E. coli.
Summary:
- A study screened 518 stool specimens from patients with acute gastroenteritis for rotavirus.
- Rotaviruses were detected in 23.3% of specimens, predominantly in hospitalized infants under six months.
- Enteropathogenic E. coli was found concurrently in 4 cases. ELISA demonstrated higher sensitivity than CF for rotavirus detection.
Impact:
- Highlights the significant role of rotavirus in infant acute gastroenteritis.
- Recommends ELISA as a superior diagnostic tool for rotavirus detection in clinical settings.
- Informs differential diagnosis strategies for acute gastroenteritis in young children.