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Updated: Sep 20, 2026
08:19
The Mouse Isolated Perfused Kidney Technique
Published on: November 17, 2016
Cortisol metabolism and excretion in the isolated perfused rat kidney
Steroids
|November 1, 1977
Abstract:
The isolated perfused rat kidney allows a simultaneous kinetic study of both the renal metabolism and the urinary excretion of cortisol and its metabolites in the rat. In this system, cortisol was completely metabolized within 120 minutes. The main renal metabolites of cortisol (cortisone, 20 reduced cortisol and 20 reduced cortisone) were found in the recirculating perfusate and in urine. The formation of these metabolites was quantitatively evaluated and compared to a theoretical model.
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