[Uricemia and uric acid quantities in urine under unbalanced diet (author's transl)]

Under exclusive intake of glucose or fat production of uric acid and growth is lowered in male rats. Just the same can be observed in adult animals. Loss in weight and impairment in production of uric acid seem to relate to each other. Growth-inhibition, i.e. weight reduction cannot be the reason for the obviously reduced synthesis of uric acid, because corresponding findings can not be ascertained in protein-fed animals in spite of weight-reduction. These findings suggest that synthesis of uric-acid depends on the intake of amino-acids. Thereby the pool of amino acids would be decisive for the synthesis-rate of nucleic acids. It might be conceivable, that the decrease of uric acid serum concentration during aging relates to the suggestion mentioned above.