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Positional information and pattern formation.

L Wolpert

    Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
    |October 7, 1981
    PubMed
    Summary
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    Cells acquire positional values, interpreted based on genetics and history, to create spatial differentiation patterns. A diffusible morphogen-like signal provides positional information in chick limb development.

    Area of Science:

    • Developmental biology
    • Cellular differentiation
    • Pattern formation

    Background:

    • Spatial patterns of cellular differentiation are crucial for development.
    • Positional information guides cell fate decisions.
    • Mechanisms of establishing positional values are diverse.

    Purpose of the Study:

    • To explore how cells acquire and interpret positional values for differentiation.
    • To investigate the role of positional signals in pattern formation.
    • To present evidence for a specific positional signal in chick limb development.

    Main Methods:

    • Conceptual framework for positional value acquisition.
    • Analysis of factors influencing positional value interpretation (genetics, history).
    • Investigation of positional signals (morphogens, progress zones, induction).

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    Main Results:

    • Positional value interpretation depends on genetic makeup and developmental history.
    • Positional signals, like morphogens or progress zones, specify positional values.
    • Positional value involves long-term memory, akin to cell determination.
    • Evidence suggests a diffusible morphogen-like signal along the antero-posterior axis in chick limb development.

    Conclusions:

    • Positional values are key to generating diverse spatial differentiation patterns.
    • Cellular interpretation of positional information is context-dependent.
    • A specific signal with morphogen-like properties is involved in chick limb antero-posterior patterning.