Interaction between ethanol and antihistamines: 3. mebhydrolin

Area of Science:

• Pharmacology
• Neuroscience
• Human Physiology

Background:

• Mebhydrolin is an antihistamine.
• Ethanol is known to impair cognitive and motor functions.

Purpose of the Study:

• To investigate the effects of mebhydrolin, alone and with ethanol, on human performance.
• To assess mebhydrolin's antihistaminic activity during ethanol interaction.

Main Methods:

• 17 student volunteers participated in the study.
• Oral administration of mebhydrolin (0.71 mg/kg) and ethanol (0.75 g/kg).
• Evaluation of perceptual, cognitive, and motor functions, along with histamine challenge tests.

Main Results:

• Mebhydrolin alone did not significantly alter performance.
• Mebhydrolin enhanced performance deficits induced by ethanol.
• The mebhydrolin dose exhibited antihistaminic effects during the ethanol interaction period.

Conclusions:

• Mebhydrolin may potentiate ethanol's impairing effects on cognitive and motor functions.
• The antihistaminic property of mebhydrolin was confirmed.
• Further research is needed to understand the implications of this interaction.