[Effect of high-fat and high-protein diets on the enzyme activity participating in hydrochloric acid secretion]

The authors studied the effect of high-fat and high-protein diets on the activity of some enzymes of rat gastric mucosa parietal cells. It was found that the high-protein diet (40% of protein in terms of caloricity) causes an increase in the activity of both the mitochondrial enzymes of Mg2+-ATPase and HCO-3-ATPase and enzymes of the plasma membrane (K+-ATPase and cytoplasm (carboanhydrase). The high-fat diet (60%) of fat in terms of caloricity) produces different effects on the above-indicated enzymes: the activity of Mg2+-ATPase decreases, while that of HCO-3-ATPase rises; at the same time the activity of K+-ATPase and carboanhydrase diminishes. It was shown that the enzymatic systems responsible for hydrochloric acid secretion in the stomach show a delicate response to a qualitatively different nutrition.