Related Experiment Videos
[Acrodermatitis enteropathica; zinc sulfate therapy]
Annales De Dermatologie Et De Venereologie
|November 1, 1977
Summary
Two siblings with acrodermatitis enteropathica showed low zinc levels. Oral zinc sulfate treatment led to symptom regression, confirming zinc
Area of Science:
- Pediatric Genetics
- Dermatology
- Nutritional Science
Background:
- Acrodermatitis enteropathica (AE) is a rare genetic disorder affecting zinc absorption.
- Early diagnosis and treatment are crucial for managing AE symptoms.
Observation:
- Two siblings presented with clinical signs of acrodermatitis enteropathica.
- Laboratory tests revealed significantly low serum zinc levels in both individuals.
Findings:
- Oral administration of zinc sulfate (100 mg daily) resulted in complete resolution of dermatological and systemic manifestations.
- Interruption of zinc therapy led to the recurrence of symptoms, which again improved upon treatment resumption.
Implications:
- These cases suggest a genetic defect in intestinal zinc absorption as the underlying cause of AE.
- Zinc sulfate therapy is a safe, effective, and potentially diagnostic treatment for acrodermatitis enteropathica.