[Effect of benzodiazepine tranquilizers on the development of toxic brain edema]

Experimental nicotinic brain edema in rats was made use of to examine the action of the benzodiazepine tranquilizers, diazepam and phenazepam. It was disclosed that these agents have antiedematous properties. It is suggested that the GABA-ergic mechanisms might participate in the realization of the effect under consideration.