Neurochemical correlates of the kindling model of epilepsy

Repeated electrical stimulation of the brain can produce many epileptogenic effects including those which characterize the kindling model. Kindling stimulation, by definition, changes the brain is such a way that formerly subconvulsive stimuli can elicit electrographic and convulsive seizure activity. In addition, the kindled animal becomes more susceptible to many, but not all, other types of seizures. These facts suggest that kindling produces brain changes which may selectively model some types of epileptiform excitability. In order to understand the basis for such changes numerous neurochemical studies have been attempted in the last few years. Although many changes have been demonstrated to be produced by kindling, few studies have been designed to specifically examine the long-lasting (permanent) neurochemical correlates of kindling stimulation. In this review, neurochemical data relevant to kindling are presented and discussed in terms of their possible significance to the seizure susceptibility changes produced by kindling.