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Related Experiment Videos

Behavioral pharmacologic studies in the monkey with DD-3480.

T Shibuya, T Nishimori, H Matsuda

    International Journal of Clinical Pharmacology, Therapy, and Toxicology
    |June 1, 1982
    PubMed
    Summary

    A new butyrophenone derivative, DD-3480, shows dose-dependent catalepsy induction in monkeys, comparable to haloperidol but shorter in duration. DD-3480 also demonstrated a slightly stronger anti-apomorphine effect than haloperidol.

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    Area of Science:

    • Neuropharmacology
    • Drug Discovery

    Background:

    • Butyrophenone derivatives are investigated for their effects on the central nervous system.
    • Haloperidol is a well-established antipsychotic with known catalepsy-inducing and anti-apomorphine properties.

    Purpose of the Study:

    • To compare the catalepsy-inducing and anti-apomorphine effects of a novel butyrophenone derivative, DD-3480, with haloperidol in a preclinical primate model.
    • To evaluate the dose-dependency and duration of DD-3480's effects.

    Main Methods:

    • A comparative study was conducted in monkeys.
    • Oral administration of DD-3480 and haloperidol at varying doses (2.5-10 mg/kg).
    • Assessment of catalepsy induction and anti-apomorphine activity.

    Main Results:

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    • DD-3480 induced catalepsy in a dose-dependent manner.
    • The catalepsy-inducing effect of DD-3480 was comparable to haloperidol, but its duration was shorter.
    • DD-3480 exhibited a slightly stronger anti-apomorphine effect than haloperidol at 2.5 mg/kg.

    Conclusions:

    • DD-3480 possesses significant catalepsy-inducing and anti-apomorphine properties in monkeys.
    • Its pharmacological profile suggests potential as a therapeutic agent, warranting further investigation.
    • The comparative data provides valuable insights into the neuropharmacological actions of novel butyrophenones.