Fluorescein dilaurate--tubeless test for pancreatic exocrine failure

The usefulness of fluorescein dilaurate as an indicator of pancreatic exocrine failure has been assessed in 70 patients and normal volunteers. The test consisted of a comparison of urinary fluorescein excretion after ingestion of fluorescein dilaurate with that after ingestion of unesterified fluorescein. The test was easy to perform and acceptable to the patients. The sensitivity of the test was 95%. There was a false-positive rate of 11% in a group of patients who had steatorrhoea which was non-pancreatic in origin. The test can be a useful screening test for the exclusion of pancreatic exocrine failure as a cause of steatorrhoea and can be conducted in outpatients.