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Updated: Aug 19, 2026

Preparation of Pancreatic Acinar Cells for the Purpose of Calcium Imaging, Cell Injury Measurements, and Adenoviral Infection
Published on: July 5, 2013
Potassium release by alpha 2-adrenergic receptor stimulation of rat parotid acinar cells
Abstract:
alpha-Adrenergic stimulation elicited a rapid release of K+ from dispersed parotid acinar cells in the presence of external Ca2+. A recent classification of alpha-adrenergic receptors proposed that alpha 1 receptors facilitate Ca2+ entry while alpha 2 receptors interact with adenylate cyclase. We tested this proposal by studying the ability of selective alpha-adrenergic antagonists to prevent epinephrine-induced release of K+ from parotid cells. The alpha 1 agents, WB 4101 and prazosin, were less potent than the alpha 2 antagonist yohimbine. These data suggest that alpha 2-adrenergic receptors in the parotid might facilitate the entry of Ca2+.
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