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Possible involvement of glutamate in electrocortical activity
Neuropharmacology
|September 1, 1982
Summary
L-glutamic acid, an excitatory amino acid, activates the electrocorticogram when injected into the brainstem reticular formation and increases cortical activity when applied to the cortex. This suggests L-glutamic acid influences brain activity regulation.
Area of Science:
- Neuroscience
- Neurophysiology
Background:
- The electrocorticogram (ECoG) reflects cortical activity.
- The mesencephalic reticular formation plays a role in regulating brain states.
Purpose of the Study:
- To investigate the effects of L-glutamic acid on electrocorticogram activity.
- To determine the role of L-glutamic acid in the mesencephalic reticular formation and cortex.
Main Methods:
- Microinjections of L-glutamic acid into the mesencephalic reticular formation.
- Topical application of L-glutamic acid to the exposed cortex.
- Electrocorticogram recording.
Main Results:
- Microinjections into the reticular formation caused ECoG activation/desynchronization.
- Topical application to the cortex increased ECoG amplitude.
- L-glutamic acid influences both subcortical and cortical electrical activity.
Conclusions:
- L-glutamic acid is implicated in the transmission of signals within the reticular formation controlling ECoG.
- L-glutamic acid may directly affect cortical neurons to modulate electrical activity.