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Related Experiment Videos

Drug interactions in controlled clinical trials.

S Gershon

    The Journal of Clinical Psychiatry
    |December 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Concomitant medications did not alter side effect profiles for buspirone, clorazepate, or placebo. However, common medications increased side effects in the diazepam group, indicating potential drug interactions.

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    Area of Science:

    • Pharmacology
    • Clinical Trial Analysis
    • Drug Safety

    Background:

    • Assessing drug interactions is crucial in clinical trials.
    • Concomitant medications are frequently used by patients with anxiety disorders.

    Purpose of the Study:

    • To compare the side effect profiles of buspirone, diazepam, clorazepate, and placebo.
    • To evaluate the impact of concomitant medications on these side effect profiles.

    Main Methods:

    • A clinical trial involving approximately 1,000 anxious patients.
    • Patients received buspirone (n=700), diazepam, clorazepate, or placebo.
    • Side effect profiles were analyzed with and without concomitant medications.

    Main Results:

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  • Concomitant medications did not affect side effect profiles for buspirone, clorazepate, and placebo groups.
  • The incidence of side effects increased in the diazepam group when taken with concomitant medications.
  • Increased sedation with diazepam and clorazepate was not attributed to concomitant medications.

    • Conclusions:

    • Buspirone and clorazepate appear to have favorable side effect profiles regarding interactions with common medications.
    • Diazepam may exhibit increased side effects when co-administered with other drugs.
    • Further research into diazepam's drug interaction potential is warranted.