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Related Experiment Videos

The histamine test in schizophrenia.

H Aggernaes, V Schultz, N Bjørum

    The Journal of Clinical Psychiatry
    |December 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    The histamine skin test, used to study schizophrenia, did not show a diminished response in patients. This suggests the histamine test is not a reliable diagnostic tool for schizophrenia.

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    Area of Science:

    • Neuroscience
    • Psychiatry
    • Pharmacology

    Background:

    • Previous research suggested a diminished cutaneous response to histamine in schizophrenic patients.
    • Neuroleptic medications are commonly used to treat schizophrenia.

    Purpose of the Study:

    • To investigate the cutaneous response to histamine in different patient groups.
    • To determine the diagnostic utility of the histamine test for schizophrenia.

    Main Methods:

    • Intradermal injection of 50 micrograms of histamine.
    • Studied nonmedicated schizophrenic patients, medicated schizophrenic patients, non-schizophrenic patients on neuroleptics, and nonmedicated controls.

    Main Results:

    • The study did not reproduce the previously reported diminished histamine response in schizophrenic patients.

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  • No significant difference in cutaneous response was observed across the studied groups.

    • Conclusions:

    • The histamine skin test is not a reliable diagnostic marker for schizophrenia.
    • Further research may be needed to understand histamine's role in schizophrenia.