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Histamine receptors in primate gallbladder.

D J Schoetz, W E Wise, W W La Morte

    Digestive Diseases and Sciences
    |April 1, 1983
    PubMed
    Summary
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    Histamine affects gallbladder pressure via H1 and H2 receptors in primates. H1-agonists increase pressure, while H2-agonists decrease it, influencing gallbladder function.

    Area of Science:

    • Gastroenterology
    • Pharmacology
    • Physiology

    Background:

    • Histamine's role in gallbladder function is not fully understood.
    • Previous studies suggest histamine influences gallbladder pressure.

    Purpose of the Study:

    • To investigate the effect of histamine on gallbladder pressure in a primate model.
    • To determine the roles of H1 and H2 receptors in mediating histamine's effects on the gallbladder.

    Main Methods:

    • Awake baboons were used to study intravenous histamine effects on intragallbladder pressure (GBp).
    • Gallbladder volume was maintained at 60-70% of resting volume.
    • Responses to H1 and H2 agonists and antagonists (diphenhydramine and metiamide) were assessed.

    Main Results:

    Related Experiment Videos

    • Histamine caused a dose-dependent increase in GBp.
    • H1-antagonist administration reduced the GBp response to histamine.
    • H2-antagonist administration enhanced the GBp response to histamine.
    • H1-agonist increased GBp, while H2-agonist decreased GBp.

    Conclusions:

    • Primate gallbladder possesses both stimulatory H1-receptors and inhibitory H2-receptors.
    • Histamine modulates gallbladder pressure through distinct H1 and H2 receptor pathways.