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Capsule filling studies using an mG2 production machine.

I G Jolliffe, J M Newton

    The Journal of Pharmacy and Pharmacology
    |February 1, 1983
    PubMed
    Summary
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    Compression affects capsule filling properties of lactose powders. Optimal nozzle surface texture and compression settings improve fill uniformity, validating simulator use for production studies.

    Area of Science:

    • Pharmaceutical Technology
    • Materials Science

    Background:

    • Capsule filling is a critical pharmaceutical manufacturing process.
    • Understanding powder flow and compressibility is essential for optimizing capsule filling.

    Purpose of the Study:

    • To investigate the impact of compression settings on lactose powder capsule filling.
    • To evaluate the effect of dosator nozzle surface texture on fill weight uniformity.
    • To validate the use of the mG2 simulator for production-scale capsule filling studies.

    Main Methods:

    • Utilized a production mG2 G36 machine to test four lactose particle size fractions.
    • Varied compression settings and nozzle bore surface textures.
    • Analyzed fill weights and powder compaction characteristics.

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    Main Results:

    • Fine, cohesive powders yielded uniform fill weights across compression settings.
    • Increasing powder flowability reduced the optimal compression range.
    • Powder compaction limited upper compression settings, impacting fill weights.
    • Resurfaced nozzles improved capsule filling uniformity, with one surface showing resilience to powder coating.

    Conclusions:

    • Compression settings significantly influence capsule filling, with optimal ranges dependent on powder flow properties.
    • Dosator nozzle surface texture plays a crucial role in achieving uniform capsule fills.
    • The mG2 simulator effectively replicates production capsule filling, serving as a valuable tool for process optimization.