New doppler technique for assessing uteroplacental blood flow

Gated, pulsed, doppler ultrasound was used to study blood flow velocity profiles in the uterine vessels (arcuate arteries) during the second and third trimesters of pregnancy. A frequency index profile nomogram was constructed from 30 normal pregnancies; this demonstrated high diastolic velocity and low pulsatility. Among 31 pregnancies with complications 14 showed waveform changes suggesting raised vascular resistance; these pregnancies were complicated with a high frequency of proteinuric hypertension, poor fetal growth, and fetal hypoxia. This non-invasive technique may give early warning of impaired uteroplacental perfusion and can be used to evaluate methods of improving uterine blood flow.