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[Pharmacological studies on oxatomide: (6) Effect on the peripheral organs]
Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica
|January 1, 1983
Summary
Oxatomide, an anti-allergic drug, demonstrated cardiovascular and gastrointestinal effects in anesthetized animals but not when orally administered. This drug showed no antigenicity in experimental models, suggesting a favorable safety profile.
Area of Science:
- Pharmacology
- Cardiovascular Physiology
- Gastrointestinal Physiology
Context:
- Oxatomide is an anti-allergic medication.
- Investigating the systemic effects of oxatomide is crucial for understanding its therapeutic applications and potential side effects.
Purpose:
- To evaluate the effects of oxatomide on cardiovascular, digestive, and autonomic nervous systems.
- To assess the in vitro and in vivo pharmacological actions of oxatomide.
- To determine the antigenicity of oxatomide.
Summary:
- Intravenous oxatomide (≥1 mg/kg) reduced blood pressure, heart rate, and gastrointestinal/uterine motility in dogs, rabbits, and rats.
- In vitro, oxatomide inhibited isolated organ movements at high concentrations (≥10⁻⁶M) and antagonized histamine (≥3x10⁻⁸M).
- Oral oxatomide (up to 100 mg/kg) showed no significant systemic effects, and the drug exhibited no antigenicity in animal models.
Impact:
- Oxatomide exhibits dose-dependent effects on physiological systems, with intravenous administration impacting cardiovascular and digestive functions.
- The lack of significant effects from oral administration and absence of antigenicity suggest a potentially safe therapeutic window for oxatomide.
- These findings contribute to the understanding of oxatomide's pharmacological profile, informing its clinical use and further research.