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Pulmonary carcinoid associated with a parathormone producing melanoma
The Journal of Dermatologic Surgery and Oncology
|July 1, 1983
Summary
This study discusses a rare case of hypercalcemia caused by ectopic parathormone production from malignant melanoma and pulmonary carcinoid. The findings suggest a potential link between melanoma and multiple endocrine neoplasia syndromes.
Area of Science:
- Endocrinology
- Oncology
- Pathology
Background:
- Hypercalcemia is a complex metabolic disturbance with various underlying causes.
- Ectopic parathormone production is a rare mechanism leading to hypercalcemia, often associated with malignancies.
Observation:
- A rare case of hypercalcemia is presented, attributed to probable ectopic parathormone (PTH) production.
- The source of ectopic PTH was identified as a malignant melanoma.
- The patient also had a co-existing pulmonary carcinoid tumor.
Findings:
- The co-occurrence of malignant melanoma and pulmonary carcinoid is unusual.
- This association suggests a potential paraneoplastic syndrome.
- The ectopic PTH production by melanoma led to significant hypercalcemia.
Implications:
- This case highlights the importance of considering ectopic hormone production in unexplained hypercalcemia.
- The findings suggest a possible association between melanoma and multiple endocrine neoplasia (MEN) syndromes.
- Further research is warranted to explore the link between melanoma, carcinoid tumors, and endocrine disorders.