[Comparative characteristics of the psychotropic activity of "atypical" tranquilizers in an experiment]

Experiments on animals were made to study pharmacological activity of "atypical" tranquilizers (nitrazepam, flunitrazepam, clobasam, tacitin, clonazepam, depakin) according to the classical methods for determination of pharmacological activity of typical anxiolytics. As regards the spectrum of pharmacological activity, "atypical" tranquilizers differ from classical anxiolytics. The anxiolytic effect exhibited by the latter group drugs with the exception of clonazepam develops in the presence of the sedative manifestations. The data obtained attest to the necessity of a comprehensive methodological approach to the assessment of "atypical" tranquilizers.