[Characteristics of fenazepam excretion in rats and mice]

Study of excretion of the tranquilizer phenazepam [7-bromo-1,3-dihydro-5-(2'-chlorophenyl)-2H-1,4-benzodiazepine-2-one] and its pharmacologically active metabolite 3-hydroxyphenazepam with urine and feces of rats and mice has shown that the drug is excreted unchanged in extremely negligible amounts. During 5 days, 11.4% of phenazepam with reference to the dose administered is excreted with mouse urine. In rats, this metabolite is detectable in the urine only after phenazepam administration in a dose of 100 mg/kg.