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Related Experiment Videos

Pulsatile insulin has greater hypoglycemic effect than continuous delivery.

D R Matthews, B A Naylor, R G Jones

    Diabetes
    |July 1, 1983
    PubMed
    Summary

    Pulsatile insulin infusion offers greater blood sugar control than steady infusion in normal subjects. This method may enhance insulin

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    Asymmetric changes in circulating insulin levels after an increase compared with a reduction in insulin pump basal rate in people with Type 1 diabetes.

    Diabetic medicine : a journal of the British Diabetic Association·2017

    Area of Science:

    • Endocrinology
    • Metabolic Research

    Background:

    • Insulin therapy is crucial for managing glucose levels.
    • Understanding optimal insulin delivery methods is essential for effective glycemic control.

    Purpose of the Study:

    • To compare the hypoglycemic effects of pulsatile versus continuous steady insulin infusions.
    • To investigate the impact of insulin infusion patterns on insulin receptor binding.

    Main Methods:

    • Six normal subjects received intravenous insulin infusions.
    • Pancreatic insulin secretion was suppressed using somatostatin-14.
    • Insulin was administered either continuously overnight or in pulsatile 2-minute bursts every 11 minutes.

    Main Results:

    • Pulsatile insulin infusion resulted in significantly lower mean plasma glucose concentrations compared to steady infusion.
    • The difference in glucose levels became significant after 7 hours.
    • Specific binding of insulin to monocytes was higher with pulsatile infusion.

    Conclusions:

    • Pulsatile intravenous insulin administration demonstrates a greater hypoglycemic effect than steady infusion.
    • Enhanced insulin receptor binding may mediate the improved efficacy of pulsatile insulin delivery.

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