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Hepatic function after anaesthesia for major vascular reconstructive surgery.

J W Sear, C Prys-Roberts, A Dye

    British Journal of Anaesthesia
    |July 1, 1983
    PubMed
    Summary
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    Althesin and di-isopropyl phenol anesthesia caused liver enzyme changes similar to halothane. These anesthetic agents, when supplementing nitrous oxide, showed comparable effects on liver function tests post-surgery.

    Area of Science:

    • Anesthesiology
    • Hepatology
    • Pharmacology

    Background:

    • Anesthetic agents can impact liver function.
    • Monitoring hepatic enzyme changes is crucial after major surgery.

    Purpose of the Study:

    • To compare the effects of Althesin, minaxolone, and di-isopropyl phenol on hepatic function.
    • To evaluate these effects against a halothane control group during major vascular surgery.

    Main Methods:

    • Patients received Althesin, minaxolone, di-isopropyl phenol, or halothane anesthesia, supplementing nitrous oxide.
    • Hepatic function tests were measured pre-operatively and on days 1, 3, 5, and 7 post-surgery.

    Main Results:

    • Aspartate amino-transferase activity increased significantly in all groups by day 3.

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  • Total lactic dehydrogenase increased with Althesin, minaxolone, and halothane.
  • No significant changes in alkaline phosphatase or ornithine carbamoyl transpeptidase were observed.

    • Conclusions:

    • Althesin and di-isopropyl phenol anesthesia induce liver enzyme changes comparable to halothane.
    • These findings suggest similar hepatic effects between these anesthetic agents and halothane when used with nitrous oxide.