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Related Experiment Videos

Decreased serum selenium in alcoholics--a consequence of liver dysfunction.

M J Välimäki, K J Harju, R H Ylikahri

    Clinica Chimica Acta; International Journal of Clinical Chemistry
    |June 15, 1983
    PubMed
    Summary

    Serum selenium levels significantly decrease in alcoholics, correlating with liver function. This reduction is linked to liver disease severity, not alcohol intake itself, highlighting selenium

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    Area of Science:

    • Biochemistry
    • Clinical Nutrition
    • Hepatology

    Background:

    • Alcoholism is associated with various nutritional deficiencies.
    • Selenium is an essential trace element with antioxidant properties.
    • Liver function significantly impacts nutrient metabolism and homeostasis.

    Purpose of the Study:

    • To investigate serum selenium concentrations in alcoholics with and without liver cirrhosis.
    • To explore the relationship between serum selenium levels and markers of liver function and alcohol consumption.
    • To compare selenium levels in alcoholic cirrhosis with other liver diseases and conditions.

    Main Methods:

    • Serum selenium levels were measured in non-cirrhotic alcoholics, cirrhotic alcoholics, healthy controls, patients with primary biliary cirrhosis, and patients with hypoalbuminemia of renal origin.

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  • Correlations between serum selenium and liver function parameters (albumin, prothrombin time, bilirubin, alkaline phosphatase, gamma-glutamyl transpeptidase) were analyzed.
  • The effect of ethanol abstinence and acute alcohol intake on serum selenium was assessed.

    • Main Results:

    • Serum selenium decreased by 17% in non-cirrhotic alcoholics and 48% in cirrhotic alcoholics compared to controls.
    • Serum selenium positively correlated with albumin and prothrombin time, and inversely with bilirubin, alkaline phosphatase, and gamma-glutamyl transpeptidase in alcoholics.
    • Serum selenium levels in primary biliary cirrhosis were similar to alcoholic cirrhotics, while normal in renal hypoalbuminemia.

    Conclusions:

    • Deterioration of liver function, regardless of cause, leads to decreased serum selenium levels.
    • Alcohol-induced liver damage significantly impacts selenium status.
    • Further research is needed to determine if impaired lipoperoxide removal contributes to reduced selenium in liver disease.