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Related Experiment Videos

Diazepam in tardive dyskinesia.

S S Weber, R L Dufresne, R E Becker

    Drug Intelligence & Clinical Pharmacy
    |July 1, 1983
    PubMed
    Summary

    This study found that diazepam did not effectively treat tardive dyskinesia movements, despite some patient improvement. Further research into behavior modification strategies is recommended for managing these involuntary movements.

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    Area of Science:

    • Neuroscience
    • Psychiatry
    • Pharmacology

    Background:

    • Tardive dyskinesia (TD) involves involuntary movements, often a side effect of antipsychotic medications.
    • GABA-ergic system facilitation is a potential therapeutic avenue for TD, with benzodiazepines like diazepam being investigated.

    Purpose of the Study:

    • To evaluate the efficacy of diazepam in treating tardive dyskinesia motor symptoms.
    • To assess the impact of diazepam on psychopathology in patients with tardive dyskinesia.

    Main Methods:

    • A 24-week, crossover study involving 13 subjects with tardive dyskinesia.
    • Administration of diazepam, with assessments using the Abnormal Involuntary Movement Scale and the Brief Psychiatric Rating Scale (BPRS).
    • Blind raters assessed motor movements and psychopathology.

    Main Results:

    • Overall improvement in movement measurements from baseline, with some reaching statistical significance.
    • No significant drug effect demonstrated; patients improved similarly with or without diazepam.
    • Psychiatric symptoms, specifically the BPRS activation factor, showed significant improvement over baseline.

    Conclusions:

    • Diazepam is not effective in managing the involuntary movements associated with tardive dyskinesia.
    • Behavior modification strategies should be explored as a potential treatment for tardive dyskinesia symptoms.

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