Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pharmacologic problems in shock research.

H R Adams

    Advances in Shock Research
    |January 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Many drugs used in cardiovascular research have multiple unintended effects. Overlooking these secondary actions can lead to inaccurate conclusions in experimental drug data analysis.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Evaluation of new instruments for screening and diagnosis of tics and tic disorders in a well-characterized sample of youth with tics and recruited controls.

    Evidence-based practice in child and adolescent mental health·2024
    Same author

    Increasing precision in the measurement of change in pediatric neurodegenerative disease.

    Molecular genetics and metabolism·2022
    Same author

    Design of a Multisite Study Assessing the Impact of Tic Disorders on Individuals, Families, and Communities.

    Pediatric neurology·2017
    Same author

    Increased T-regulatory cells within lymphocyte follicles in moderate COPD.

    The European respiratory journal·2009
    Same author

    Endotoxin impairs agonist-stimulated intracellular free calcium (Ca(i)) responses in freshly dispersed aortic endothelial cells.

    Shock (Augusta, Ga.)·2001
    Same author

    PET evaluation of [(18)F]FCWAY, an analog of the 5-HT(1A) receptor antagonist, WAY-100635.

    Nuclear medicine and biology·2000
    Same journal

    Isotopic approaches to the estimation of protein requirements in burn patients.

    Advances in shock research·1983
    Same journal

    Effect of a new synthetic complement inhibitor on hepatic glycolytic intermediates in septic rats.

    Advances in shock research·1983
    Same journal

    Development of a primate model of exposure hypothermia.

    Advances in shock research·1983
    Same journal

    Effect of hypothermia on survival time and ECG in rats with acute blood loss.

    Advances in shock research·1983
    Same journal

    Metabolism of prolonged shock.

    Advances in shock research·1983
    Same journal

    Cerebral, coronary, and renal blood flows during hemorrhagic hypotension in anesthetized miniature swine.

    Advances in shock research·1983
    See all related articles

    Area of Science:

    • Pharmacology
    • Cardiovascular Research
    • Drug Discovery

    Background:

    • Receptor-selective agonists and antagonists are increasingly used as tools in cardiovascular research.
    • The complexity of drug actions is often underestimated in experimental settings.

    Purpose of the Study:

    • To highlight the limitation of single-biologic action for exogenous chemicals used in research.
    • To discuss how subsidiary pharmacologic actions can affect data interpretation.

    Main Methods:

    • Appraisal of prototype drugs commonly used in cardiovascular research.
    • Theoretical discussion on the impact of unconsidered drug actions.

    Main Results:

    • Few exogenous chemicals exhibit only a single biologic action.

    Related Experiment Videos

  • Lack of consideration for secondary pharmacologic effects can lead to oversimplified interpretations.

    • Conclusions:

    • Researchers must account for all pharmacologic actions of drugs used experimentally.
    • A comprehensive understanding of drug effects is crucial for accurate cardiovascular research.